European Journal of Dermatology
MENUType 2 segmental Darier disease Volume 9, numéro 6, September 1999
Illustrations
Department of Dermatology, University of Marburg, Deutschhausstrasse 9, 35033 Marburg, Germany.
- Page(s) : 449-51
- Année de parution : 1999
Darier disease is an autosomal dominant skin disorder (OMIM 124 200) caused by mutations in the ATP2A2 gene that encodes an intracellular Ca2+ pump [1]. This defect of the Ca2+-signalling pathway results in a disturbed adhesion of keratinocytes that gives rise to characteristic histopathological changes in the form of acantholysis and dyskeratosis [2]. Clinical features consist of disseminated brownish and pruritic papules [...]