JLE

Epileptic Disorders

MENU

Functional brain connectivity in electrical status epilepticus in sleep Volume 21, numéro 1, February 2019

Illustrations


  • Figure 1

  • Figure 2

  • Figure 3

  • Figure 4

  • Figure 5

  • Figure 6

  • Figure 7

  • Figure 8

Tableaux

Auteurs
1 Department of Pediatrics, University of California, Irvine
2 Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
3 National Institute of Mental Health, National Institutes of Health
4 Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA
* Correspondence: Gregory L. Holmes Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Stafford Hall 118C, Burlington, VT 05405, USA

Aims

Electrical status epilepticus in sleep (ESES) is an age-related, self-limited epileptic encephalopathy. The syndrome is characterized by cognitive and behavioral abnormalities and a specific EEG pattern of continuous spikes and waves during slow-wave sleep. While spikes and sharp waves are known to result in transient cognitive impairment during learning and memory tasks performed during the waking state, the effect of epileptiform discharges during sleep on cognition and behavior is unclear. There is increasing evidence that abnormalities of coherence, a measure of the consistency of the phase difference between two EEG signals when compared over time, is an important feature of brain oscillations and plays a role in cognition and behavior. The objective of this study was to determine whether coherence of EEG activity is altered during slow-wave sleep in children with ESES when compared to typically developing children.