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 Printable version |
Update of pernicious anemia |
Hématologie. Volume 15, Number 6, 473-7, novembre-décembre 2009, Mini-revue
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 Résumé
Texte intégral
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Author(s) : Fatou Samba Diago Ndiaye, Seynabou Fall, Anna Sarr, Saleh Dine Laraki, Mamadou Mourtalla Ka, Thérèse Moreira Diop |
Summary : Purpose. The aim of this study was to describe the present clinical characteristics of the pernicious anemia (PA). Method. It is a retrospective (2000-2007) study of 26 patients presenting an established cobalamin deficiency related to PA. Results. The median age of the patients was 51 years (24-79), the male/female ratio 0.73. The median delay of the diagnosis was 16 months (6-48). Various clinical manifestations, mainly neurological in 42.3%, cutaneous in 42,3% and gastric in 61,5 % were at least one hematological abnormalities in 100 %. Average serum vitamin B12 was very low in 84,6% (n \= 22) of cases. Anti-intrinsic factor or anti-parietal gastric cells antibodies were found in all the cases. All the followed patients were successfully treated with intramuscular (n \= 25) or oral crystalline cyanocobalamin (n \= 1). Conclusions. PA may be responsible of various clinical manifestations or biological abnormalities\; and oral crystalline cyanocobalamin treatment may be successful. |
Keywords : pernicious anemia, update, Senegal |
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