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 Printable version |
Biology of the platelet and megakaryocyte in vascular pathology |
Hématologie. Volume 1, Number 4, 283-8, Juillet - Août 1995, REVUES ET MINI-REVUES
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 Résumé
Article gratuit
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Author(s) : John F. Martin, Angie S. Brown |
Summary : Platelets are heterogeneous in size and reactivity. They are produced from a uniquely large polyploid cell found in the bone marrow, the megakaryocyte. The platelet megakaryocyte axis forms a dynamic equilibrium varying in normal biology and in disease. Prolonged platelet destruction leads to the production of large platelets from large, high ploidy megakaryocytes. In vivo and ex vivo studies show that such platelets have more haemostatic potential than smaller less dense platelets. The importance of platelet reactivity in atherosclerosis and the evidence suggesting that prothrombotic changes in the megakaryocyte platelet haemostatic axis precede coronary artery thrombosis will be reviewed. |
Keywords : atherosclerosis, megakaryocyte, thrombopoiesis, platelet, platelet activation. |
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